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Electrophoresis and Immunofixation of the Proteins of Serum, Urine and Cerebrospinal Fluid By: Borek Janik, Ph.D. Electrophoresis and immunofixation procedures for the separation and identification of the proteins of serum, urine, and cerebrospinal fluid (CSF) conform to certain rules that concern the procedures themselves, the samples and the clinical-diagnostic interpretation of the results. Each procedure also has its own idiosyncrasies. This guide addresses the choice of samples, their storage and treatment, procedural artifacts, detection limits and procedural parameters. Next, the guide presents guidelines to the interpretation of results and finally the major disorders and conditions associated with abnormal electrophoretic and immunofixation patterns are discussed.