Bio - Sebia's mission is to improve the solution for every clinical electrophoresis laboratory by increasing productivity through improved technology and by providing both traditional and innovative electrophoresis assays producing only the highest quality results.
- Sebia Electrophoresis is 100% focused on the science of electrophoresis. At least 10% of the annual budget is dedicated to research and development of electrophoresis products.
• Products - Sebia's electrophoresis systems automate traditional electrophoresis testing providing substantial labor and cost savings to clinical laboratories.
• Reimbursement - Are you looking for a reason to bring electrophoresis testing back in-house? Perhaps you already perform protein electrophoresis in your laboratory and would like to add additional assays to your in-house electrophoresis menu?
& Feedback - Communication is one of the key elements of success. One of the many ways Sebia works towards maintaining a dynamic two-way communication with its customers is by publishing a quarterly newsletter.
Conferences - Compelling electrophoresis topics presented by electrophoresis authorities and specialists in a discussion-type format. Continuing education units are available.
- As a growing company in the medical diagnostic industry, Sebia offers a variety of challenging career opportunities. Sebia, Inc. is an equal opportunity employer and, as such, believes in providing applicants and employees with employment opportunities based on ability, accomplishments and initiative.
• FAQ - In an effort to simplify the science of electrophoresis we are providing the reader with information on a few key subjects.
Gel Electrophoresis - Sebia Electrophoresis is the worldwide
leader in the production of the most innovative electrophoresis
tools, including gel electrophoresis instrumentation - HYDRASYS®.
Electrophoresis Equipment - The future of electrophoresis is automated electrophoresis equipment. And at Sebia, the future is today. Our company is proud to be the global leader in the production of automated electrophoresis equipment.
Electrophoresis Equipment - In the process of electrophoresis, proteins
are separated and characterized according to attributes
like size and charge when moved across an applied
electric field. Once the proteins have been completely
separated, technologists can easily find abnormalities
according to the types and density of proteins located
in the sample, allowing physicians to diagnose disease
Transferrin - Alcohol abuse represents a major health
problem in the United States and around the world.
In order to help doctors, nurses, and other medical
professionals in evaluating alcohol consumption with
regards to a diagnosis and monitoring, an accurate
indicator of alcohol abuse is required.
• Electrophoresis - Electrophoresis is the process of separating
and characterizing proteins in an applied electric
field. Proteins are major components of muscle, enzymes,
hormones, hemoglobin, and other body tissues, and
every protein in the human body is of a specific charge,
size, shape, and solubility.
• Hemoglobin A1c - A hemoglobin A1c electrophoresis test is one of the most important tools today in monitoring diabetes. During this process of electrophoresis, hemoglobin molecules are moved across an electric field. Because of their varying electrical charges, the different types of hemoglobin will separate into several different “bands.”
Electrophoresis - Hemoglobin electrophoresis is a test that is performed to measure the different types of hemoglobin in a person’s blood. It is performed when a doctor suspects that a patient has a genetic disease or disorder that stems from having abnormal hemoglobin, such as sickle cell anemia. In this form of electrophoresis, the hemoglobin particles are placed in an electric field.
Electrophoresis - Lipoproteins are the molecules which carry
cholesterol and triglycerides throughout the body.
They are both vital to daily bodily functions like
building cell membranes, hormones, and providing energy
to body tissue. However, an excess of either, in particular
cholesterol, can put a person at serious risk for
Protein Electrophoresis - Serum protein electrophoresis is a test that measures specific proteins in the blood and is used to evaluate, diagnose, and monitor a variety of diseases and conditions. Protein electrophoresis can be performed using a patient’s blood, urine or CSF sample.
• Educational Material - Sebia is dedicated to the continuing education of our customers in the area of electrophoresis. Unless otherwise noted, these educational materials are provided free of charge. To order, navigate to the order form by clicking on the link at the bottom of each page, indicate your selection(s) and then complete the form.
• Blount Memorial Hospital - If this were a perfect world, everything would happen according to a nice, neat established plan. Work would flow in well–timed increments. Staffing levels would be like Goldilock's favorite porridge
• Cedars-Sinai Medical Center - When you're the largest non-profit hospital in the Western United States — and one of the most renowned medical centers in the world — you consistently attract a high volume of patients. Which leads to a consistently high volume of lab work.
• Centrex Clinical Laboratories, Inc. - Resolution is what the medical laboratory is all about - determining causes and finding cures for complex conditions. Yet many high volume labs in today's cost-sensitive healthcare environment are struggling to resolve a growing problem: the limited supply of personnel.
• Central Pennsylvania Alliance Laboratory - There's no replacing the human touch in laboratory medicine. However, human intervention can increase the variability of test results. Dr. Robert Elser can attest to that.
• Duke University Medical Center - Janet Mueller is here to tell you that even a prestigious, world-renowned medical institution isn't immune to the same pains afflicting hospitals everywhere.
• Medical Center of Louisiana at New Orleans - In a city that practically implores people to sit back, relax and wile away the hours, there's at least one group of professionals that doesn't believe in "downtime."
• Memorial Hospital
- Memorial Hospital in Chattanooga, Tennessee came to this realization after routinely sending out electrophoresis work to an outside source. When the volume started increasing monthly, Memorial lab colleagues determined that too much money was going out the door with each outsourced test.
• General Medical Laboratory - In an era that celebrates individualism, it's hard to imagine an organization wanting people to act exactly alike. But then again, most organizations don't hold the fate of individual lives in their hands.
• NewYork-Presbyterian Hospital - It's not easy to earn a spot on the "Top 10" list of U.S. hospitals. It's even harder keeping up with the amount of business this attracts.
• Research & Diagnostic Laboratories - When a lab technologist takes time out of a hectic day to talk at length about the thrill of a new instrument, it must be something special. In fact, Tom Chase is so ebullient about the Sebia HYDRASYS® electrophoresis system, it makes one wonder how he got along without it.
• St. John Health System - There's no such thing as spring, summer or winter break for the core lab of a Wayne State University-affiliated teaching hospital. In fact, the tests keep being piled on.
• St. Marys - Since the lab began using the Sebia HYDRASYS® electrophoresis system in January 1999, technologists exert less effort preparing reagents
less time running electrophoresis
and less eyestrain interpreting results.
• University Health Care System - Since 1818, University Hospital has served the medical needs of the Augusta, Georgia community. Today, it is much more than a hospital. It has emerged as a multi-faceted not-for-profit health care system offering a comprehensive and integrated range of health care services in the Central Savannah River Area.
• University of Iowa - The University of Iowa has a rich history of groundbreaking medical discoveries and firsts. Its nickname, the Hawkeyes, means "keen vision." So then, it's no surprise that one of its labs found a leading-edge solution to cut electrophoresis time considerably.
• Biotech One at UMass Health Care - The employees of Biotech One lab at UMass Memorial Health Care aren't unreasonably demanding — but they would have every reason to be. After all, they're accustomed to getting more from automation than the typical quality and efficiency boost.
• University of Michigan Hospitals - That's the game plan for most every health care system today
and the University of Michigan Hospitals — part of the University of Michigan Health System — is no exception.
• Acid Hemoglobin - Acid Hemoglobin is the companion kit to Sebia' Alkaline Hemoglobin assay and is intended to differentiate abnormal hemoglobins such as S from D and C from E. These abnormal hemoglobins, which co-migrate with others in an alkaline pH, can be readily identified by visual interpretation when compared to their patterns electrophoresed at an acid pH.
• Alkaline Hemoglobin - Sebia's Alkaline Hemoglobin assay is intended for the separation of normal hemoglobins and the major hemoglobin variants at an alkaline pH. Designed to give better separation between A and F hemoglobins than traditional agarose assays, hemoglobins A, A2, F, S and C can be easily separated and identified utilizing the Alkaline assay for initial screening and Sebia's Acid Hemoglobin assay for confirmation of variant migration.
• Alkaline Phosphatase - Sebia's ISO-PAL assay is designed to separate the isoenzymes of alkaline phosphatase found in serum. Alkaline Phosphatase is an enzyme normally present in high concentrations in growing bone and in bile, but it is present in many human tissues including liver, bone, kidney, intestine and placenta.
• Apolipoprotein A1B- Perfect for the research laboratory, Apo A1B is designed to provide the simultaneous quantification of apolipoproteins A and B1in serum. Apo A1 is one of the major components of HDL which plays a major role in the transport of cholesterol to the liver for metabolism.
• Bence Jones - Bence Jones is another innovative Sebia product. This assay is designed to type, with only one test, any monoclonal proteins found in urine samples. This assay is unique in that unconcentrated urine is used eliminating the cost and time involved in concentrating fluids.
• CAPILLARYS - Sebia's innovative capillary electrophoresis system is designed to optimize and completely automate electrophoresis testing. The CAPILLARYS utilizes liquid flow electrophoresis for applications in the clinical diagnostic setting.
• Immunotyping - Immunotyping (IT), Sebia's patented alternative to immunofixation testing, is designed for the detection and characterization of monoclonal proteins in serum. All sample dilutions are completely automated; standard or nonstandard dilutions (for hypo- or hypergamma samples) are performed on the CAPILLARYS system.
• CAPILLARYS Protein 6 - Designed for the separation of serum proteins in alkaline buffer on Sebia's capillary electrophoresis instrument — CAPILLARYS. A high voltage protein separation is performed and direct protein detection takes place at 200 nm. Normal major proteins separate into six fractions — albumin, alpha-1, alpha-2, beta-1, beta-2 and gamma globulins.
• LDL/HDL Cholesterol Direct - LDL/HDL CHOL Direct is an innovative and improved assay for the direct measurement of the major predictive parameters for coronary heart disease, LDL and HDL.
• controls - All controls are provided in a stabilized lyophilized form and once reconstituted, can be aliquoted and frozen for future use — up to six months.
• CSF - CSF is another innovative assay Sebia has developed specifically to detect and identify immunoglobulin based oligoclonal patterns in unconcentrated spinal fluid. There are several benefits of using unconcentrated spinal fluid. First, the time and cost of concentrating a fluid is eliminated.
• CSF Isoelectric Focusing (CSF IEF) Assay - CSF IEF takes Sebia's CSF assay a step further by utilizing isoelectric focusing for clear, crisp banding and easy result interpretation. IEF, now considered the gold standard for this assay, is the most sensitive method for the detection of oligoclonal immunoglobulin bands.
• Hemoglobin A1c - Hb A1c has been shown to be the most stable form of glycated hemoglobin and the least affected by fluctuations in blood glucose levels. It has become the best choice for use as a monitoring tool in the management of diabetes.
• Hemoglobin Control: Hb AFSC - Sebia's Hb AFSC Control provides excellent resolution of normal hemoglobins A & F and abnormal hemoglobins S & C. The control is designed for use with Sebia's Hydragel® Hemoglobin and Hydragel® Acid Hemoglobin assays.
• High Resolution - High Resolution is the ultimate in protein separation and is designed for all fluid types including serum, urine and CSF. Qualitative or quantitative, this gel is unsurpassed in resolution and high sensitivity needed for the detection of very weak fractions and oligoclonal banding.
• Hydragel K20 System - Hydragel K20 is Sebia's quality line of manual agarose gel electrophoresis products. Samples are applied utilizing the same patented applicator combs that is used for sample application on the HYDRASYS® semi-automated electrophoresis system.
• ASSIST - Eliminating the need for any manual pipetting, the ASSIST delivers precise micro-volumes of sample directly from primary tubes to four HYDRASYS sample applicators contained in a built-in humidity chamber.
• ASSIST - Sebia's semi-automated agarose gel electrophoresis system is designed to automate the many tedious steps involved in classic electrophoresis and immunofixation testing.
• Immunofixation - Sebia's Immunofixation assay is designed for the identification of gammopathies in human sera or other human biological fluids, including concentrated urine. The sample is first electrophoresed. An innovative labor saving method is used to greatly simplify antisera application.
• ISO-CK - ISO-CK is designed for the separation of the three main isoenzymes of creatine kinase, MM, MB, and BB. Commonly used for the timing and monitoring of cardiac evens, this truly unique assay produces colorimetric results instead of the traditional fluorescent patterns.
• ISO-LDH -The Sebia ISO-LDH kit is designed to provide a clear separation of the five lactate dehydrogenase isoenzymes commonly found in serum. Elevations in LDH isoenzymes can occur as a result of numerous physiological problems including a heart attack and liver disease. LD1 is associated with heart muscle, LD2 with skeletal muscle, and LD5 with the liver.
• Lipoproteins - Useful in the diagnostic determination of hyperlipidemia, the Sebia LIPO assay is designed for the separation and quantitation of the major lipoprotein components found in serum.
• Lipoprotein + Lp(a) - Useful in the diagnostic determination of hyperlipidemia, the Sebia LIPO assay is designed for the separation and quantitation of the major lipoprotein components found in serum.
• Lp (a) - The Hydragel Lp (a) assay is designed for the quantification of Lp (a) lipoprotein in serum by an electroimmunodiffusion technique. Lp (a) is a plasmatic lipoprotein with physico-chemical and clinical properties very close to LDL. Lp (a) competes with plasminogen for fibrin binding and is also involved in atherosclerosis as well as thrombotic disease.
• LP A1 Particles - The Hydragel LP A1 Particles assay is designed for the quantification of LP A1 particles in serum utilizing an electroimmunodiffusion technique. The initials LP followed by the apolipoprotein designation, such as LP A1, now designate particles containing lipids and one apolipoprotein.
• LP CIII Particles - The Hydragel LP CIII Particles assay is designed for the quantification of total Apo CIII and Apo CIII present in particles without Apo B by an electroimmunodiffusion technique. CIII apolipoprotein is found either in atherogeneous lipoproteins LDL-VLDL as well as in the protective lipoproteins HDL.
• LP E Particles - The Hydragel LP E Particles assay is designed for the quantification of total Apo E and Apo E present in particles without Apo B by an electroimmunodiffusion technique. LP E is found in both atherogenous lipoproteins, such as LDL, IDL and VLDL, associated with Apo B and in non atherogeneous lipoproteins, HDL.
• IF Penta - One of Sebia's most unique kits, the IF Penta assay is designed as a screening immunofixation. Penta is considered a true and complete immunofixation assay. It contains all antisera utilized in a traditional immunofixation; however, it streamlines the test procedure thus expediting the processing of large workloads.
• Phoresis Imaging System - The Phoresis is a state-of-the-art digital imaging system which allows scanning and storage of electrophoresis results from any Sebia gel including immunofixation. This system provides benefits to any size laboratory.
• Protein - Sebia's Protein assay provides unsurpassed resolution and sensitivity for the detection of abnormal proteins such as monoclonal proteins and also for the identification of any abnormal distribution of proteins consistent with certain disease states.
• Protein b1+b2 - The Protein b1+b2 gel is designed to provide additional separation, or higher resolution, in the beta region between the protein bands of transferrin and complement (C3) without any additional time required for electrophoresis. The resulting pattern can either be delimited into the traditional five fractions or into six protein fractions (Albumin, Alpha-1, Alpha-2, Beta-1, Beta-2, and Gamma).
• Protein Controls: Normal & Hypergamma - Sebia's Normal and Hypergamma Controls are designed to be run on either agarose gels or Sebia's CAPILLARYS™ system. Our unique control manufacturing process preserves complement, as well as the other serum components, presenting a complete serum profile.
• Proteinuria - Proteinuria is an innovative assay designed to classify conditions of proteinuria as either tubular, glomerular, mixed, or overload. Free light chain screening can simultaneously also be performed with this one test. The composition and porosity of this gel allows the separation of proteins according to their molecular weights.
• Reagents to Meet any Laboratory Requirement- Sebia offers a complete agarose gel electrophoresis test menu allowing full workload consolidation. Kit configurations of 7, 15, 30, or 54 samples per gel and 2, 4, or 9 for immunofixation assays allow maximum throughput while eliminating waste.
• Urine Profile- Sebia's comprehensive assay is a unique approach to urine profiling. The classification of proteinuria as tubular, glomerular, mixed, or overload is combined with the identification of any monoclonal component.
• Reimbursement- Could your laboratory benefit from the realization of additional Medicare reimbursement dollars? Are you aware that a simple electrophoretic assay such as Immunofixation can bring as much as $52.71 per test into your lab?
• Electrophoresis: Medicare Reimbursement - Are you looking for a reason to bring electrophoresis testing back in-house? Perhaps you already perform protein electrophoresis in your laboratory and would like to add additional assays to your in-house electrophoresis menu?