|
Aid in the diagnosis of hemoglobinopathies and thalassemia
View an introduction to
hemoglobinopathy testing by CE technology.
Capillary electrophoresis (CE) technology is utilized to separate, detect, and quantify normal hemoglobins and
hemoglobin variants. This assay has been adapted to the Sebia capillary electrophoresis instruments -
CAPILLARYS 2 and MINICAP in order to provide complete automation. Direct analysis is performed from
the bar-coded, primary tube on packed, unwashed red blood cells. Red cell hemolysate is automatically
prepared on the instrument; sample migration occurs; and relative quantification and presumptive
identification of the hemoglobin fractions take place. Multiple capillaries functioning in parallel,
yet independently, allow for high-throughput result analysis
CAPILLARYS 2 – up to 33 results per hour; MINICAP – up to 8 results per hour.
Sebia’s Hemoglobin assay via capillary electrophoresis provides the following:
Complete automation from hemolysate preparation to relative quantification &
presumptive identification of hemoglobin fractions
Minimal sample requirement, as is the nature of capillary electrophoresis technology
Positive ID with bar-coded, primary tube sampling
Easy-to-interpret, clean result curves without extraneous peaks
Enhanced resolution and focalization in the separation of variants and accurate quantification of
Hb A2, F, and S with impressive correlation with HPLC
Separation of Hb E from the A2 fraction, facilitating identification and quantification
Clearly detectable and identifiable Hb H and Bart’s, as seen in alpha-thalassemia
Stored Hb AFSC Control reference curve overlay, facilitating variant ID such as closely migrating
Hb S from Hb D and G
| P/N |
Description |
| 2007 |
CAPILLARYS Hemoglobin |
| 2227 |
MINICAP Hemoglobin |
| 4778 |
Normal Hb A2 Control/ Migration control |
| 4779 |
Pathological Hb A2 Control |
| 4792 |
Hb AFSC Control |
|
